Modulation of MNK activity affects translation of mRNAs involved in cancer development, progression, and their resistance to therapies. Serine/threonine kinases MNK1/MNK2 inhibition Down-regulates eIF4E by S209 phosphorylation on eIF4E. Downregulation of eIF4E does not impact normal cellular function but appears to make the cell less likely to exhibit tumor phenotype.